DoE Optimization Empowers the Automated Preparation of Enantiomerically Pure [18F]Talazoparib and its In Vivo Evaluation as a PARP Radiotracer-Reference-Cited by-同舟云学术

DoE Optimization Empowers the Automated Preparation of Enantiomerically Pure [18F]Talazoparib and its In Vivo Evaluation as a PARP Radiotracer

Published:2021-10-21 Issue:21 Volume:64 Page:15690-15701
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bowden Gregory D.¹²^ORCID,Stotz Sophie¹²^ORCID,Kinzler Johannes¹,Geibel Christian³,Lämmerhofer Michael³^ORCID,Pichler Bernd J.¹²⁴,Maurer Andreas¹²^ORCID

Affiliation:

1. Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Roentgenweg 15, 72076 Tuebingen, Germany

2. Cluster of Excellence iFIT (EXC 2180) “Image-Guided and Functionally Instructed Tumor Therapies”, Eberhard Karls University, Roentgenweg 13, 72076 Tuebingen, Germany

3. Institute of Pharmaceutical Sciences, Department of Pharmaceutical (Bio-)Analysis, Eberhard Karls University, Auf der Morgenstelle 8, 72076 Tuebingen, Germany

4. German Cancer Research Center, German Cancer Consortium DKTK, Partner Site Tuebingen, Roentgenweg 13, 72076 Tuebingen, Germany

Funder

Werner Siemens-Stiftung

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00903

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1. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase