Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain-Reference-Cited by-同舟云学术

Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain

Published:2021-12-21 Issue:1 Volume:65 Page:485-496
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Adams Gregory L.¹^ORCID,Pall Parul S.¹,Grauer Steven M.¹,Zhou Xiaoping¹,Ballard Jeanine E.¹,Vavrek Marissa¹,Kraus Richard L.¹,Morissette Pierre¹,Li Nianyu¹,Colarusso Stefania²,Bianchi Elisabetta²^ORCID,Palani Anandan³,Klein Rebecca¹,John Christopher T.¹,Wang Deping¹,Tudor Matthew¹^ORCID,Nolting Andrew F.¹^ORCID,Biba Mirlinda⁴^ORCID,Nowak Timothy³,Makarov Alexey A.⁴^ORCID,Reibarkh Mikhail⁴^ORCID,Buevich Alexei V.³^ORCID,Zhong Wendy⁴^ORCID,Regalado Erik L.⁴^ORCID,Wang Xiao⁴^ORCID,Gao Qi⁴^ORCID,Shahripour Aurash¹,Zhu Yuping³,de Simone Daniele²,Frattarelli Tommaso²,Pasquini Nicolo’ Maria²,Magotti Paola²,Iaccarino Roberto²,Li Yuxing¹,Solly Kelli¹,Lee Keun-Joong⁴,Wang Weixun¹,Chen Feifei¹,Zeng Haoyu¹,Wang Jixin¹,Regan Hilary¹,Amin Rupesh P.¹,Regan Christopher P.¹,Burgey Christopher S.¹,Henze Darrell A.¹,Sun Chengzao¹,Tellers David M.¹^ORCID

Affiliation:

1. Merck & Co., Inc., West Point, Pennsylvania 19486, United States

2. Peptides and Small Molecules R&D Department, IRBM Spa, Via Pontina km 30.600, 00071 Pomezia (RM), Italy

3. Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

4. Merck & Co., Inc., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01570

Reference53 articles.