Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria-Reference-Cited by-同舟云学术

Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria

Published:2022-04-15 Issue:8 Volume:65 Page:6088-6099
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gurvic Dominik¹^ORCID,Leach Andrew G.²³^ORCID,Zachariae Ulrich¹^ORCID

Affiliation:

1. Computational Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom

2. Division of Pharmacy and Optometry, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom

3. Medchemica Limited, Mereside, Alderley Park, Macclesfield, SK10 4TG, United Kingdom

Funder

Medical Research Council

Helperby Ltd.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01984

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4. Outer membrane permeability and antibiotic resistance

5. Permeation rates of penicillins indicate that Escherichia coli porins function principally as nonspecific channels

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