Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy

Author:

Zhang Jifa1,Tang Pan1,Zou Ling1,Zhang Jin12,Chen Juncheng1,Yang Chengcan1,He Gu1ORCID,Liu Bo1ORCID,Liu Jie1,Chiang Cheng-Ming3ORCID,Wang Guan1ORCID,Ye Tinghong1,Ouyang Liang1ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center, Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041 Sichuan, China

2. School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, China

3. Simmons Comprehensive Cancer Center, Department of Pharmacology, and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States

Funder

National Cancer Institute

Ministry of Education of the People's Republic of China

Health Commission of Sichuan Province

China Postdoctoral Science Foundation

Cancer Prevention and Research Institute of Texas

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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