Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease-Reference-Cited by-同舟云学术

Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease

Published:2021-06-18 Issue:13 Volume:64 Page:9100-9119
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Armani Elisabetta¹^ORCID,Rizzi Andrea¹,Capaldi Carmelida¹,De Fanti Renato¹,Delcanale Maurizio¹,Villetti Gino¹,Marchini Gessica¹,Pisano Anna Rita¹,Pitozzi Vanessa¹,Pittelli Maria Gloria¹,Trevisani Marcello¹,Salvadori Michela¹,Cenacchi Valentina¹,Puccini Paola¹,Amadei Francesco¹,Pappani Alice¹,Civelli Maurizio¹,Patacchini Riccardo¹,Baker-Glenn Charles A.G.²,Van de Poël Hervé²,Blackaby Wesley P.²,Nash Kevin²,Amari Gabriele¹

Affiliation:

1. Nuovo Centro Ricerche, Chiesi Farmaceutici S.p.A., Largo Belloli 11/a, 43122 Parma, Italy

2. Chesterford Research Park, Charles River Discovery Research Services UK Ltd, Saffron Walden CB10 1XL, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00204

Reference12 articles.

1. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

2. The MABA approach: a new option to improve bronchodilator therapy

3. GS-5759, a Bifunctional β2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells

4. First dual M3 antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6-diaminopyrimidine derivatives

5. Callahan, J. F.; Wan, Z.; Yan, H. Dual pharmacophores - PDE4-muscarinic antagonistics. WO2009100170, Aug 13, 2009.

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