Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease
Author:
Affiliation:
1. Nuovo Centro Ricerche, Chiesi Farmaceutici S.p.A., Largo Belloli 11/a, 43122 Parma, Italy
2. Chesterford Research Park, Charles River Discovery Research Services UK Ltd, Saffron Walden CB10 1XL, United Kingdom
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00204
Reference12 articles.
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2. The MABA approach: a new option to improve bronchodilator therapy
3. GS-5759, a Bifunctional β2-Adrenoceptor Agonist and Phosphodiesterase 4 Inhibitor for Chronic Obstructive Pulmonary Disease with a Unique Mode of Action: Effects on Gene Expression in Human Airway Epithelial Cells
4. First dual M3 antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6-diaminopyrimidine derivatives
5. Callahan, J. F.; Wan, Z.; Yan, H. Dual pharmacophores - PDE4-muscarinic antagonistics. WO2009100170, Aug 13, 2009.
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