Harnessing Reversed Allosteric Communication: A Novel Strategy for Allosteric Drug Discovery

Author:

Fan Jigang123,Liu Yaqin4,Kong Ren5ORCID,Ni Duan6,Yu Zhengtian7,Lu Shaoyong124ORCID,Zhang Jian1248ORCID

Affiliation:

1. College of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, China

2. State Key Laboratory of Oncogenes and Related Genes, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China

3. Zhiyuan Innovative Research Center, Shanghai Jiao Tong University, Shanghai 200240, China

4. Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China

5. Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou 213001, China

6. The Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia

7. Nutshell Therapeutics, Shanghai 201203, China

8. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China

Funder

Shanghai Municipal Education Commission

National Natural Science Foundation of China

Zhiyuan Scholar Program

Shanghai Science and Technology Innovation

Shanghai Health and Family Planning System Excellent Subject Leader and Excellent Young Medical Talents Training Program

CAMS Innovation Fund for Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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