Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1-Reference-Cited by-同舟云学术

Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1

Published:2021-12-30 Issue:1 Volume:65 Page:757-784
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Casimiro-Garcia Agustin¹^ORCID,Allais Christophe²^ORCID,Brennan Agnes³,Choi Chulho²^ORCID,Dower Gabriela³,Farley Kathleen A.²^ORCID,Fleming Margaret³,Flick Andrew²,Frisbie Richard K.²,Hall Justin²,Hepworth David¹,Jones Hannah¹,Knafels John D.²,Kortum Steve²,Lovering Frank E.¹,Mathias John P.¹,Mohan Sashi³,Morgan Paul M.³,Parng Chuenlei¹,Parris Kevin²,Pullen Nick³,Schlerman Franklin³,Stansfield John⁴,Strohbach Joseph W.¹,Vajdos Felix F.²,Vincent Fabien²,Wang Hong²,Wang Xiaolun¹^ORCID,Webster Robert¹,Wright Stephen W.²

Affiliation:

1. Medicine Design, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States

2. Medicine Design, Pfizer Inc., 445 Eastern Point Rd, Groton, Connecticut 06340, United States

3. Inflammation and Immunology Research Unit, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States

4. Early Clinical Development Non-Clinical Statistics, Pfizer Inc., 1 Portland Street, Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01849

Reference53 articles.

1. PPARalpha regulates the production of serum Vanin-1 by liver

2. Diverse biological activities of the vascular non-inflammatory molecules – The Vanin pantetheinases

3. Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice

4. The Linkage Between Coenzyme A Metabolism and Inflammation: Roles of Pantetheinase

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