Identification of a Novel 2,8-Diazaspiro[4.5]decan-1-one Derivative as a Potent and Selective Dual TYK2/JAK1 Inhibitor for the Treatment of Inflammatory Bowel Disease-Reference-Cited by-同舟云学术

Identification of a Novel 2,8-Diazaspiro[4.5]decan-1-one Derivative as a Potent and Selective Dual TYK2/JAK1 Inhibitor for the Treatment of Inflammatory Bowel Disease

Published:2022-02-03 Issue:4 Volume:65 Page:3151-3172
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Tao¹,Cui Xue¹,Tang Minghai¹,Qi Wenyan¹,Zhu Zejiang¹,Shi Mingsong¹,Yang Linyu¹,Pei Heying¹,Zhang Wanhua²,xie Lixin¹,Xu Yaohui¹,Yang Zhuang¹³,Chen Lijuan¹³^ORCID

Affiliation:

1. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China

2. Department of Hematology, West China Hospital of Sichuan University, Chengdu 610041, China

3. Chengdu Zenitar Biomedical Technology Co., Ltd., Chengdu 610041, China

Funder

Department of Science and Technology of Sichuan Province

National Natural Science Foundation of China

West China hospital, Sichuan University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01137