Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death-Reference-Cited by-同舟云学术

Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death

Published:2021-08-02 Issue:15 Volume:64 Page:11445-11459
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Russo Luigi¹,Mascanzoni Fabiola²,Farina Biancamaria²,Dolga Amalia Mihaela³⁴^ORCID,Monti Alessandra²,Caporale Andrea²,Culmsee Carsten³,Fattorusso Roberto¹^ORCID,Ruvo Menotti²^ORCID,Doti Nunzianna²^ORCID

Affiliation:

1. Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “L. Vanvitelli”, Via Vivaldi 43, 81100 Caserta, Italy

2. Institute of Biostructures and Bioimaging (IBB)-CNR, Via Mezzocannone, 16, 80134 Napoli, Italy

3. Institute of Pharmacology and Clinical Pharmacy, University of Marburg, 35043 Marburg, Germany

4. Faculty of Science and Engineering, Groningen Research Institute of Pharmacy (GRIP), Research School of Behavioural and Cognitive Neurosciences (BCN), Department of Molecular Pharmacology, University of Groningen, 9713 AV Groningen, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00777

Reference74 articles.

1. The crystal structure of the mouse apoptosis-inducing factor AIF

2. Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation

3. Oxidative stress, cell cycle, and neurodegeneration

4. The harlequin mouse mutation downregulates apoptosis-inducing factor

5. Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia

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