Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation-Reference-Cited by-同舟云学术

Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation

Published:2021-07-19 Issue:15 Volume:64 Page:11496-11526
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Neukirch Konstantin¹²^ORCID,Alsabil Khaled³,Dinh Chau-Phi³,Bilancia Rossella⁴,Raasch Martin⁵,Ville Alexia³,Cerqua Ida⁴,Viault Guillaume³,Bréard Dimitri³,Pace Simona²,Temml Veronika⁶,Brunner Elena²,Jordan Paul M.²,Marques Marta C.⁷,Loeser Konstantin²,Gollowitzer André¹²,Permann Stephan¹,Gerstmeier Jana²,Lorkowski Stefan⁸,Stuppner Hermann⁹^ORCID,Garscha Ulrike¹⁰,Rodrigues Tiago⁷,Bernardes Gonçalo J. L.⁷¹¹^ORCID,Schuster Daniela⁶^ORCID,Séraphin Denis³^ORCID,Richomme Pascal³,Rossi Antonietta⁴,Mosig Alexander S.⁵^ORCID,Roviezzo Fiorentina⁴,Werz Oliver²^ORCID,Helesbeux Jean-Jacques³,Koeberle Andreas¹²^ORCID

Affiliation:

1. Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria

2. Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich Schiller University Jena, 07743 Jena, Germany

3. Univ Angers, SONAS, SFR QUASAV, F-49000 Angers, France

4. Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy

5. Institute of Biochemistry II, Jena University Hospital, 07747 Jena, Germany

6. Department of Pharmaceutical and Medicinal Chemistry, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria

7. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal

8. Department of Nutritional Biochemistry and Physiology, Institute of Nutritional Science and Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Halle-Jena-Leipzig, Friedrich Schiller University Jena, 07743 Jena, Germany

9. Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria

10. Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Greifswald, 17489 Greifswald, Germany

11. Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, U.K.

Funder

Agence Nationale de la Recherche

Freistaat Th??ringen

Deutscher Akademischer Austauschdienst

Austrian Science Fund

Deutsche Forschungsgemeinschaft

European Social Fund

Ministero della Universit?? e della Ricerca

Publisher