Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine-Reference-Cited by-同舟云学术

Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine

Published:2021-07-07 Issue:14 Volume:64 Page:10059-10101
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sayama Misa¹,Uwamizu Akiharu²³,Ikubo Masaya¹,Chen Luying¹,Yan Ge¹,Otani Yuko¹^ORCID,Inoue Asuka³⁴⁵,Aoki Junken²³,Ohwada Tomohiko¹^ORCID

Affiliation:

1. Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

2. Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

3. AMED-LEAP, Japan Science and Technology Corporation, Kawaguchi 332-0012, Japan

4. Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan

5. AMED-PRIME, Japan Science and Technology Corporation, Kawaguchi 332-0012, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00347

Reference30 articles.

1. Identification of a lysophosphatidylserine receptor on mast cells