From Structure Modification to Drug Launch: A Systematic Review of the Ongoing Development of Cyclin-Dependent Kinase Inhibitors for Multiple Cancer Therapy-Reference-Cited by-同舟云学术

From Structure Modification to Drug Launch: A Systematic Review of the Ongoing Development of Cyclin-Dependent Kinase Inhibitors for Multiple Cancer Therapy

Published:2022-04-29 Issue:9 Volume:65 Page:6390-6418
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shi Zhenfeng¹,Tian Lei²³,Qiang Taotao²^ORCID,Li Jingyi³,Xing Yue³,Ren Xiaodong⁴,Liu Chang⁵,Liang Chengyuan³^ORCID

Affiliation:

1. Department of Urology Surgery Center, The People’s Hospital of Xinjiang Uyghur Autonomous Region, Urumqi 830002, P. R. China

2. College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi’an 710021, P. R. China

3. Faculty of Pharmacy, Shaanxi University of Science & Technology, Xi’an 710021, P. R. China

4. Medical College, Guizhou University, Guiyang 550025, P. R. China

5. Zhuhai Jinan Selenium Source Nanotechnology Co., Ltd., Zhuhai 519030, P. R. China

Funder

China Postdoctoral Science Foundation

Education Department of Shaanxi Province

National Natural Science Foundation of China

Natural Science Foundation of Shaanxi Province

Xinjiang Tianshan Innovation Team Foundation

Key Scientific Research Group of Shaanxi Province

Youth Innovation Team of Shaanxi Universities

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02064

Reference216 articles.

1. Allostery governs Cdk2 activation and differential recognition of CDK inhibitors

2. Inhibition of cyclin-dependent kinase 5 activity alleviates diabetes-related cognitive deficits

3. Pharmacological relevance of CDK inhibitors in Alzheimer's disease

4. Targeting Dysregulated Cell Cycle and Apoptosis for Polycystic Kidney Disease Therapy

5. The history and future of targeting cyclin-dependent kinases in cancer therapy

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