Cinchona Alkaloid-Inspired Urea-Containing Autophagy Inhibitor Shows Single-Agent Anticancer Efficacy-Reference-Cited by-同舟云学术

Cinchona Alkaloid-Inspired Urea-Containing Autophagy Inhibitor Shows Single-Agent Anticancer Efficacy

Published:2021-09-24 Issue:19 Volume:64 Page:14513-14525
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jin Pei-Ru¹,Ta Yen-Nhi Ngoc¹,Chen I-Ting²,Yu Yan-Ning¹,Hsieh Hsin Tzu¹,Nguyen Van-Anh Thi¹,Hsieh Shang-Ying¹,Hsia Tiffaney¹³,Liu Hao⁴,Hsu Chan-Wei⁵,Han Jeng-Liang²⁵^ORCID,Chen Yunching¹^ORCID

Affiliation:

1. Institute of Biomedical Engineering and Frontier Research Center on Fundamental and Applied Sciences of Matters, National Tsing Hua University, Hsinchu 30013, Taiwan

2. Department of Chemistry, National Chung Hsing University, 145 Xingda Rd., South District, Taichung City 40227, Taiwan

3. Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, United States

4. Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, United States

5. Department of Chemistry, Chung Yuan Christian University, Taoyuan City 320314, Taiwan

Funder

Ministry of Education

National Health Research Institutes

Ministry of Science and Technology, Taiwan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01036

Reference42 articles.

1. Autophagy: Renovation of Cells and Tissues

2. Regulation Mechanisms and Signaling Pathways of Autophagy

3. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

4. Pancreatic cancers require autophagy for tumor growth

5. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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