Synthesis, Biological Evaluation, and Molecular Modeling Studies of 3,4-Diarylpyrazoline Series of Compounds as Potent, Nonbrain Penetrant Antagonists of Cannabinoid-1 (CB<sub>1</sub>R) Receptor with Reduced Lipophilicity-Reference-Cited by-同舟云学术

Synthesis, Biological Evaluation, and Molecular Modeling Studies of 3,4-Diarylpyrazoline Series of Compounds as Potent, Nonbrain Penetrant Antagonists of Cannabinoid-1 (CB₁R) Receptor with Reduced Lipophilicity

Published:2022-01-27 Issue:3 Volume:65 Page:2374-2387
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Iyer Malliga R.¹^ORCID,Cinar Resat²^ORCID,Wood Casey M.¹,Zawatsky Charles N.²,Coffey Nathan J.³,Kim Kyu Ah¹,Liu Ziyi²,Katz Alexis³^ORCID,Abdalla Jasmina³,Hassan Sergio A.⁴^ORCID,Lee Yong-Sok⁴^ORCID

Affiliation:

1. Section on Medicinal Chemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Rockville, Maryland 20852, United States

2. Section on Fibrotic Disorders, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Rockville, Maryland 20852, United States

3. Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Rockville, Maryland 20852, United States

4. Bioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, United States

Funder

U.S. Department of Health and Human Services

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01836

Reference46 articles.

1. Diabesity: an overview of a rising epidemic

2. Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy

3. The Endocannabinoid System as an Emerging Target of Pharmacotherapy

4. The endocannabinoid system: a general view and latest additions

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evaluation of the Therapeutic Potential of Sulfonyl Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors;Molecules;2024-06-26

2. Pharmacological Evaluation of Cannabinoid Receptor Modulators Using GRABeCB2.0 Sensor;International Journal of Molecular Sciences;2024-05-03

3. CIRCE: Web-Based Platform for the Prediction of Cannabinoid Receptor Ligands Using Explainable Machine Learning;Journal of Chemical Information and Modeling;2023-09-07

4. Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid-1 Receptor Antagonists for Metabolic Syndrome Disorders;Journal of Medicinal Chemistry;2023-08-23

5. Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years;Pharmacological Reviews;2023-05-10