Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria

Author:

Workman Sean D.12ORCID,Day Jonathan3,Farha Maya A.45ORCID,El Zahed Sara S.45ORCID,Bon Chris12,Brown Eric D.45ORCID,Organ Michael G.367ORCID,Strynadka Natalie C. J.12ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada

2. Centre for Blood Research, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada

3. Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada

4. Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada

5. Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4L8, Canada

6. Centre for Catalysis Research and Innovation, University of Ottawa, 30 Marie-Curie Private, Ottawa, Ontario K1N 6N5, Canada

7. Department of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis-Pasteur Private, Ottawa, Ontario K1N 6N5, Canada

Funder

Howard Hughes Medical Institute

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

GlycoNet

Ontario Research Fund

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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