Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors-Reference-Cited by-同舟云学术

Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors

Published:2021-12-30 Issue:1 Volume:65 Page:838-856
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Keylor Mitchell H.¹^ORCID,Gulati Anmol¹^ORCID,Kattar Solomon D.¹,Johnson Rebecca E.¹,Chau Ryan W.¹,Margrey Kaila A.¹,Ardolino Michael J.¹^ORCID,Zarate Cayetana¹,Poremba Kelsey E.¹,Simov Vladimir¹,Morriello Gregori J.²,Acton John J.²,Pio Barbara²,Yan Xin¹^ORCID,Palte Rachel L.¹,McMinn Spencer E.¹,Nogle Lisa¹,Lesburg Charles A.¹^ORCID,Adpressa Donovon¹,Lin Shishi²,Neelamkavil Santhosh²,Liu Ping¹,Su Jing²,Hegde Laxminarayan G.¹,Woodhouse Janice D.¹,Faltus Robert¹,Xiong Tina¹,Ciaccio Paul J.¹,Piesvaux Jennifer¹,Otte Karin M.¹,Wood Harold B.²,Kennedy Matthew E.¹,Bennett David Jonathan¹,DiMauro Erin F.¹,Fell Matthew J.¹,Fuller Peter H.¹

Affiliation:

1. Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

2. Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

Funder

Merck

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01968

Reference90 articles.