Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers-Reference-Cited by-同舟云学术

Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers

Published:2021-10-05 Issue:19 Volume:64 Page:14153-14164
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Irie Takayuki¹^ORCID,Asami Tokiko¹,Sawa Ayako¹,Uno Yuko¹,Taniyama Chika²,Funakoshi Yoko²,Masai Hisao³^ORCID,Sawa Masaaki¹^ORCID

Affiliation:

1. Research and Development, Carna Biosciences, Inc., 3F BMA, 1-5-5 minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan

2. Ginkgo Biomedical Research Institute, Research and Development Department, SBI Biotech Co., Ltd., Izumi Garden Tower 15F, 1-6- Roppongi, Minato-ku, Tokyo 106-6015, Japan

3. Department of Basic Medical Sciences, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01319

Reference28 articles.

1. Cdc7 kinase complex: A key regulator in the initiation of DNA replication

2. How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

3. Eukaryotic Chromosome DNA Replication: Where, When, and How?

4. Identification of Mcm2 Phosphorylation Sites by S-phase-regulating Kinases

5. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: invitro phosphorylation of MCM subunits by a putative human homologue of Cdc7

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