Systematic Optimization of Potent and Orally Bioavailable Purine Scaffold as a Dual Inhibitor of Toll-Like Receptors 7 and 9-Reference-Cited by-同舟云学术

Systematic Optimization of Potent and Orally Bioavailable Purine Scaffold as a Dual Inhibitor of Toll-Like Receptors 7 and 9

Published:2021-06-18 Issue:13 Volume:64 Page:9279-9301
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kundu Biswajit¹,Raychaudhuri Deblina²,Mukherjee Ayan¹,Sinha Bishnu Prasad³,Sarkar Dipika¹,Bandopadhyay Purbita²³,Pal Sourav¹³,Das Nirmal¹³,Dey Debdeep⁴,Ramarao Kantubhukta¹,Nagireddy Kasireddy¹,Ganguly Dipyaman²³,Talukdar Arindam¹³^ORCID

Affiliation:

1. Department of Organic and Medicinal Chemistry, CSIR—Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Kolkata 700032, West Bengal, India

2. IICB-Translational Research Unit of Excellence, Department of Cancer Biology and Inflammatory Disorders, CSIR—Indian Institute of Chemical Biology, CN6, Sector V, Salt Lake, Kolkata 700091, West Bengal, India

3. Academy of Scientific and Innovative Research, Ghaziabad 201002, India

4. Tata Medical Center, Newtown, Kolkata 700160, West Bengal, India

Funder

Nickel Producers Environmental Research Association

Council of Scientific and Industrial Research

University Grants Commission

Science and Engineering Research Board

Department of Biotechnology , Ministry of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine