MPLA-Adjuvanted Liposomes Encapsulating S-Trimer or RBD or S1, but Not S-ECD, Elicit Robust Neutralization Against SARS-CoV-2 and Variants of Concern

Author:

Wang Jian1,Yin Xu-Guang2,Wen Yu1,Lu Jie1,Zhang Ru-Yan1,Zhou Shi-Hao1,Liao Chun-Miao1,Wei Hua-Wei3,Guo Jun1ORCID

Affiliation:

1. Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan 430079, China

2. School of Medical Sciences, Shaoxing University, Zhejiang 312000, China

3. Jiangsu East-Mab Biomedical Technology Co. Ltd, Nantong 226499, China

Funder

State Administration of Foreign Experts Affairs

Ministry of Education of the People's Republic of China

Ministry of Science and Technology of the People's Republic of China

Central China Normal University

National Natural Science Foundation of China

Wuhan Bureau of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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