Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors

Published:2021-05-12 Issue:10 Volume:64 Page:6745-6764
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Weber Csaba¹,Sipos Melinda¹,Paczal Attila¹,Balint Balazs¹,Kun Vilibald¹,Foloppe Nicolas²,Dokurno Pawel²^ORCID,Massey Andrew J.²^ORCID,Walmsley David Lee²,Hubbard Roderick E.²,Murray James²^ORCID,Benwell Karen²,Edmonds Thomas³,Demarles Didier⁴,Bruno Alain³,Burbridge Mike³,Cruzalegui Francisco³,Kotschy Andras¹^ORCID

Affiliation:

1. Servier Research Institute of Medicinal Chemistry, Záhony u. 7., H-1031 Budapest, Hungary

2. Vernalis (R&D) Ltd., Granta Park, CB21 6GB Cambridge, U.K.

3. Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy-sur-Seine, France

4. Technologie Servier, 27 Rue Eugène Vignat, 45000 Orleans, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00023

Reference31 articles.

1. Sequence Characteristics, Subcellular Localization, and Substrate Specificity of DYRK-related Kinases, a Novel Family of Dual Specificity Protein Kinases

2. Down syndrome--recent progress and future prospects

3. First Selective Dual Inhibitors of Tau Phosphorylation and Beta-Amyloid Aggregation, Two Major Pathogenic Mechanisms in Alzheimer’s Disease

4. A novel DYRK1A (Dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro

5. The role of DYRK1A in neurodegenerative diseases

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Furo[3,2-b]pyridine: Chemical synthesis, transformations and biological applications;Journal of Saudi Chemical Society;2024-09

2. Efficient synthesis and molecular docking analysis of quinazoline and azole hybrid derivatives as promising agents for anti-cancer and anti-tuberculosis activities;Journal of Molecular Structure;2024-08

3. Discovery of ZJCK-6-46: A Potent, Selective, and Orally Available Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor for the Treatment of Alzheimer’s Disease;Journal of Medicinal Chemistry;2024-07-23

4. Microscale thermophoresis (MST) and spectral shift (SpS) in drug discovery;TrAC Trends in Analytical Chemistry;2024-07

5. Discovery of a novel DYRK1A inhibitor with neuroprotective activity by virtual screening and in vitro biological evaluation;Molecular Diversity;2024-06-04

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3