Optimization of a Pyrimidinone Series for Selective Inhibition of Ca<sup>2+</sup>/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain-Reference-Cited by-同舟云学术

Optimization of a Pyrimidinone Series for Selective Inhibition of Ca²⁺/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain

Published:2022-03-10 Issue:6 Volume:65 Page:4667-4686
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Scott Jason A.¹,Soto-Velasquez Monica¹,Hayes Michael P.¹,LaVigne Justin E.¹,Miller Heath R.¹,Kaur Jatinder¹^ORCID,Ejendal Karin F. K.¹,Watts Val J.¹²³,Flaherty Daniel P.¹²³^ORCID

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States

2. Purdue Institute for Drug Discovery, West Lafayette, Indiana 47907, United States

3. Purdue Institute for Integrative Neuroscience, 207 South Martin Jischke Dr. West Lafayette, Indiana 47907, United States

Funder

National Institute of Neurological Disorders and Stroke

Indiana Clinical and Translational Sciences Institute

National Institute of Mental Health

Purdue Institute for Drug Discovery

College of Pharmacy, Purdue University

Publisher

American Chemical Society (ACS)