Novel Macrocyclic Peptidomimetics Targeting the Polo-Box Domain of Polo-Like Kinase 1

Author:

Ryu SeongShick123,Park Jung-Eun4,Ham Young Jin2,Lim Daniel C.5,Kwiatkowski Nicholas P.67,Kim Do-Hee28,Bhunia Debabrata2,Kim Nam Doo9,Yaffe Michael B.510,Son Woolim3,Kim Namkyoung123,Choi Tae-Ik11,Swain Puspanjali11,Kim Cheol-Hee11,Lee Jin-Young12,Gray Nathanael S.13ORCID,Lee Kyung S.4ORCID,Sim Taebo123ORCID

Affiliation:

1. KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea

2. Chemical Kinomics Research Center, Korea Institute of Science and Technology, 5 Hwarangro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea

3. Severance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea

4. Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States

5. Koch Institute for Integrative Cancer Research, and Center for Precision Cancer Medicine, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, United States

6. Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, United States

7. Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States

8. Department of Chemistry, College of Convergence and Integrated Science, Kyonggi University, 154 Gwanggyosan-ro, Yeongtong-gu, Suwon 16227, Republic of Korea

9. Voronoibio Inc., 32 Songdogwahak-ro, Yeonsu-gu, Incheon 21984, Republic of Korea

10. Divisions of Acute Care Surgery, Trauma, and Surgical Critical Care, and Surgical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, United States

11. Department of Biology, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea

12. Department of Biological Sciences, Keimyung University, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Republic of Korea

13. Department of Chemical and Systems Biology, ChEM-H, Stanford Cancer Institute, Stanford School of Medicine, Stanford University, 290 Jane Stanford Way, Stanford, California 94305, United States

Funder

National Institute of Environmental Health Sciences

Ministry of Education

KU-KIST Graduate School of Converging Science and Technology

National Research Foundation of Korea

Korea Institute of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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