Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X-ray Structural Studies-Reference-Cited by-全球学者库

Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X-ray Structural Studies

Published:2021-09-16 Issue:19 Volume:64 Page:14702-14714
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ghosh Arun K.¹^ORCID,Raghavaiah Jakka¹,Shahabi Dana¹,Yadav Monika¹,Anson Brandon J.²,Lendy Emma K.³,Hattori Shin-ichiro⁴,Higashi-Kuwata Nobuyo⁴,Mitsuya Hiroaki⁵⁶⁴,Mesecar Andrew D.²³^ORCID

Affiliation:

1. Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, United States

2. Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, United States

3. Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, United States

4. Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Shinjuku, Tokyo 162-8655, Japan

5. Department of Hematology and Infectious Diseases, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan

6. Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, Maryland 20892, United States

Funder

National Institute of Allergy and Infectious Diseases

Japan Agency for Medical Research and Development

National Center for Global Health and Medicine

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01214

Reference53 articles.

1. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

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3. Covid-19 — Navigating the Uncharted

4. Sustaining containment of COVID-19: global sharing for pandemic response

5. World Health Organization. Coronavirus disease (COVID-19) Situation Report, https://www.who.int/emergencies/diseases/novel-coronavirus-2019

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