Discovery of Aryl Benzoyl Hydrazide Derivatives as Novel Potent Broad-Spectrum Inhibitors of Influenza A Virus RNA-Dependent RNA Polymerase (RdRp)-Reference-Cited by-同舟云学术

Discovery of Aryl Benzoyl Hydrazide Derivatives as Novel Potent Broad-Spectrum Inhibitors of Influenza A Virus RNA-Dependent RNA Polymerase (RdRp)

Published:2022-02-25 Issue:5 Volume:65 Page:3814-3832
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Xinjin¹,Liang Jinsen²,Yu Yongshi²^ORCID,Han Xin²,Yu Lei¹,Chen Feifei¹,Xu Zhichao²,Chen Qi¹,Jin Mengyu²,Dong Chune²,Zhou Hai-Bing²³^ORCID,Lan Ke¹,Wu Shuwen¹

Affiliation:

1. State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China

2. Frontier Science Center for Immunology and Metabolism, Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China

3. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Funder

Ministry of Science and Technology of the People's Republic of China

Central University Basic Research Fund of China

National Natural Science Foundation of China

Hubei Province

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01257