Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310-Reference-Cited by-同舟云学术

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310

Published:2021-03-08 Issue:6 Volume:64 Page:2953-2966
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Safina Brian S.¹,McKerrall Steven J.¹^ORCID,Sun Shaoyi²,Chen Chien-An³,Chowdhury Sultan²,Jia Qi²,Li Jun¹,Zenova Alla Y.²,Andrez Jean-Christophe²,Bankar Girish²,Bergeron Philippe¹,Chang Jae H.¹^ORCID,Chang Elaine²,Chen Jun¹,Dean Richard²,Decker Shannon M.²,DiPasquale Antonio¹,Focken Thilo²^ORCID,Hemeon Ivan²,Khakh Kuldip²,Kim Amy¹,Kwan Rainbow²,Lindgren Andrea²,Lin Sophia²,Maher Jonathan¹,Mezeyova Janette²,Misner Dinah¹,Nelkenbrecher Karen²,Pang Jodie¹,Reese Rebecca¹,Shields Shannon D.¹,Sojo Luis²,Sheng Tao²,Verschoof Henry²,Waldbrook Matthew²,Wilson Michael S.²,Xie Zhiwei²,Young Clint²,Zabka Tanja S.¹,Hackos David H.¹,Ortwine Daniel F.¹,White Andrew D.³^ORCID,Johnson J.P.²,Robinette C. Lee²,Dehnhardt Christoph M.²^ORCID,Cohen Charles J.²,Sutherlin Daniel P.¹

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Xenon Pharmaceuticals, Inc., 200-3650 Gilmore Way, Burnaby, British Columbia V5G 4W8, Canada

3. Chempartner, Building No. 5, 998 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, P.R. China

Funder

Genentech

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00049