Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase-Reference-Cited by-同舟云学术

Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

Published:2021-06-09 Issue:12 Volume:64 Page:8579-8598
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Messore Antonella¹,Corona Angela²^ORCID,Madia Valentina Noemi¹,Saccoliti Francesco³,Tudino Valeria¹,De Leo Alessandro¹,Ialongo Davide¹,Scipione Luigi¹^ORCID,De Vita Daniela⁴,Amendola Giorgio⁵^ORCID,Novellino Ettore⁶^ORCID,Cosconati Sandro⁵^ORCID,Métifiot Mathieu⁷,Andreola Marie-Line⁷,Esposito Francesca²,Grandi Nicole²,Tramontano Enzo²^ORCID,Costi Roberta¹^ORCID,Di Santo Roberto¹^ORCID

Affiliation:

1. Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur-Fondazione Cenci Bolognetti, “Sapienza” Università di Roma, p.le Aldo Moro 5, I-00185 Rome, Italy

2. Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, SS554-09042 Monserrato (CA), Italy

3. D3 PharmaChemistry, Italian Institute of Technology, Via Morego 30, I-16163 Genova, Italy

4. Department of Environmental Biology, “Sapienza” University of Rome, p.le Aldo Moro 5, I-00185 Rome, Italy

5. DiSTABiF, University of Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta, Italy

6. Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy

7. Laboratoire MFP, UMR 5234, CNRS - Université de Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux cedex, France

Funder

Sapienza Universit?? di Roma

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00535

Reference69 articles.

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2. NIH. FDA-approved HIV medicines. https://aidsinfo.nih.gov/understanding-hiv-aids/fact-sheets/21/58/fda-approved-hiv-medicines (accessed Feb 18, 2021).

3. NYSDOH. HIV guidelines. https://www.hivguidelines.org/antiretroviral-therapy/what-to-start/#tab_1 (accessed Feb 18, 2021).

4. The Use of Highly Active Antiretroviral Therapy (HAART) in Patients With Advanced HIV Infection

5. A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other “Shock” Drugs

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