Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling-Reference-Cited by-同舟云学术

Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling

Published:2022-02-02 Issue:3 Volume:65 Page:1898-1914
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yelland Tamas¹,Garcia Esther¹,Parry Charles²,Kowalczyk Dominika¹,Wojnowska Marta³,Gohlke Andrea²^ORCID,Zalar Matja²⁴,Cameron Kenneth²,Goodwin Gillian²⁵,Yu Qing⁶,Zhu Peng-Cheng⁶,ElMaghloob Yasmin¹,Pugliese Angelo²⁵,Archibald Lewis⁷,Jamieson Andrew⁷^ORCID,Chen Yong Xiang⁶^ORCID,McArthur Duncan²⁵,Bower Justin²,Ismail Shehab¹⁸^ORCID

Affiliation:

1. CRUK Beatson Institute, Glasgow G61 1BD, United Kingdom

2. Drug Discovery Program, CRUK Beatson Institute, Glasgow G61 1BD, United Kingdom

3. School of Chemistry, University of St Andrews, North Haugh, St Andrews KY16 9ST, United Kingdom

4. School of Chemical Engineering and Analytical Sciences, Faculty of Science and Engineering, University of Manchester, Manchester M13 9PL, United Kingdom

5. BioAscent Discovery Ltd, Biocity, Motherwell ML1 5UH, United Kingdom

6. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China

7. School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom

8. Department of Chemistry, KU Leuven, Celestijnenlaan 200G, Heverlee 3001, Belgium

Funder

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01265