Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket-Reference-Cited by-同舟云学术

Dynorphin Neuropeptides Decrease Apparent Proton Affinity of ASIC1a by Occluding the Acidic Pocket

Published:2021-08-30 Issue:18 Volume:64 Page:13299-13311
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Leisle Lilia¹,Margreiter Michael²³,Ortega-Ramírez Audrey¹,Cleuvers Elinor¹,Bachmann Michèle¹,Rossetti Giulia²⁴⁵^ORCID,Gründer Stefan¹^ORCID

Affiliation:

1. Institute of Physiology, RWTH Aachen University, 52074 Aachen, Germany

2. Computational Biomedicine−Institute for Advanced Simulation/Institute of Neuroscience and Medicine, Forschungszentrum Jülich, 52425 Jülich, Germany

3. Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany

4. Jülich Supercomputing Center (JSC), Forschungszentrum Jülich, 52425 Jülich, Germany

5. Department of Neurology, RWTH Aachen University, 52074 Aachen, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00447

Reference62 articles.

1. A molecular view of the function and pharmacology of acid-sensing ion channels

2. ASIC‐like, proton‐activated currents in rat hippocampal neurons

3. A proton-gated cation channel involved in acid-sensing

4. Acid-Sensing Ion Channel 1 Is Localized in Brain Regions with High Synaptic Density and Contributes to Fear Conditioning

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