Discovery of New Imidazo[2,1-b]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising In Vitro and In Vivo Anti-melanoma Activity-Reference-Cited by-同舟云学术

Discovery of New Imidazo[2,1-b]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising In Vitro and In Vivo Anti-melanoma Activity

Published:2021-05-17 Issue:10 Volume:64 Page:6877-6901
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Abdel-Maksoud Mohammed S.¹,El-Gamal Mohammed I.²³⁴^ORCID,Lee Bong S.⁵,Gamal El-Din Mahmoud M.¹,Jeon Hong R.⁶,Kwon Dow⁵,Ammar Usama M.⁷,Mersal Karim I.⁸⁹,Ali Eslam M. H.⁸⁹,Lee Kyung-Tae¹⁰¹¹^ORCID,Yoo Kyung Ho¹²,Han Dong Keun¹³^ORCID,Lee Jae Kyun¹⁴^ORCID,Kim Garam¹⁵,Choi Hong Seok¹⁵,Kwon Young Jik¹⁶¹⁷^ORCID,Lee Kwan Hyi⁸¹⁸^ORCID,Oh Chang Hyun⁸

Affiliation:

1. Medicinal & Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (NRC), Dokki, Giza 12622, Egypt

2. Department of Medicinal Chemistry, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab Emirates

3. Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates

4. Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura 35516, Egypt

5. CTC SCIENCE, 38, Hyundaikia-ro, Paltan-myeon, Hwaseong-si, Gyeonggi-do 18576, Republic of Korea

6. CTCBIO Inc., 450-34, Noha-ri, Paltan-myeon, Hwaseong-si, Gyeonggi-do 18576, Republic of Korea

7. Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0NR, Scotland, United Kingdom

8. Center for Biomaterials, Korea Institute of Science & Technology (KIST), Seongbuk-gu, Hwarangro 14-gil 5, Seoul 136-791, Seoul, Republic of Korea

9. Department of Biomolecular Science, University of Science & Technology (UST), Daejeon, Yuseong-gu 34113, Republic of Korea

10. Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea

11. Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea

12. Chemical Kinomics Research Center, Korea Institute of Science & Technology (KIST), Seoul 136-791, Republic of Korea

13. Department of Biomedical Science, CHA University, Gyeonggi 13488, Republic of Korea

14. Center for Neuro-Medicine, Korea Institute of Science & Technology (KIST), Seongbuk-gu, Hwarangro 14-gil 5, Seoul 136-791, Seoul, Republic of Korea

15. College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea

16. Department of Chemical Engineering and Materials Science, University of California, Irvine, California 92697, United States

17. Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, United States

18. KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea

Funder

University of Sharjah

Korea Institute of Science and Technology

CTCBIO Inc

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00230

Reference47 articles.

1. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

2. Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.

3. Structure and biological activity of human homologs of the raf/mil oncogene.

4. The Human Homologs of the raf ( mil ) Oncogene Are Located on Human Chromosomes 3 and 4

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