Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe-Reference-Cited by-同舟云学术

Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe

Published:2022-03-14 Issue:6 Volume:65 Page:4972-4990
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tamayo Nuria A.¹^ORCID,Bourbeau Matthew P.¹,Allen Jennifer R.¹,Ashton Kate S.¹,Chen Jian Jeffrey¹,Kaller Matthew R.¹,Nguyen Thomas T.¹,Nishimura Nobuko¹,Pettus Liping H.¹^ORCID,Walton Mary¹,Belmontes Brian²,Moriguchi Jodi²,Chen Kui³,McCarter John D.³,Hanestad Kelly²,Chung Grace²,Ninniri Maria Stefania S.²,Sun Jan²,Poppe Leszek⁴,Spahr Chris⁴,Hui John⁴^ORCID,Jia Lei⁵,Wu Tian⁶,Dahal Upendra P.⁷,Edson Katheryne Z.⁸,Payton Marc²

Affiliation:

1. Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States

2. Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States

3. Discovery Technologies, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States

4. Discovery Attribute Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States

5. Computational & Data Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States

6. Pre-Pivotal Drug Product, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States

7. Pharmacokinetics and Drug Metabolism, Amgen Research, 1120 Veterans Blvd., South San Francisco, California 94080, United States

8. Pharmacokinetics and Drug Metabolism, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States

Funder

Amgen

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02030

Reference35 articles.

1. Genetic instabilities in human cancers

2. Targeted anti-mitotic therapies: can we improve on tubulin agents?

3. Targeting Mitosis in Cancer: Emerging Strategies

4. Kinesins and cancer

5. The Kinesin-8 Motor Kif18A Suppresses Kinetochore Movements to Control Mitotic Chromosome Alignment

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