Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain-Reference-Cited by-同舟云学术

Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain

Published:2022-03-09 Issue:6 Volume:65 Page:4534-4564
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Luo Guanglin¹^ORCID,Chen Ling¹,Kostich Walter A.²,Hamman Brian³,Allen Jason³,Easton Amy²,Bourin Clotilde²,Gulianello Michael²,Lippy Jonathan⁴,Nara Susheel⁵,Pattipati Sreenivasulu Naidu⁵,Dandapani Kumaran⁵,Dokania Manoj⁵,Vattikundala Pradeep⁵,Sharma Vivek⁵,Elavazhagan Saravanan⁵,Verma Manoj Kumar⁵,Lal Das Manish⁵,Wagh Santosh⁵,Balakrishnan Anand⁶,Johnson Benjamin M.⁶^ORCID,Santone Kenneth S.⁶,Thalody George⁷,Denton Rex⁷,Saminathan Hariharan⁵,Holenarsipur Vinay K.⁵,Kumar Anoop⁵,Rao Abhijith⁵,Putlur Siva Prasad⁵,Sarvasiddhi Sarat Kumar⁵,Shankar Ganesh⁵,Louis Justin V.⁵,Ramarao Manjunath⁵,Conway Charles M.²,Li Yu-Wen²,Pieschl Rick²,Tian Yuan²,Hong Yang²,Bristow Linda²,Albright Charles F.²,Bronson Joanne J.¹,Macor John E.¹,Dzierba Carolyn D.¹

Affiliation:

1. Department of Neuroscience Chemistry, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492, United States

2. Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492, United States

3. Lexicon Pharmaceuticals, 8800 Technology Forest Place, The Woodlands, Texas 77381, United States

4. Department of Lead Evaluation, Bristol Myers Squibb Company, Route 206 & Province Line Rd, Princeton, New Jersey 08543, United States

5. Biocon-Bristol Myers Squibb Research and Development Centre, Biocon Park, Plot No. 2 & 3, Bommasandra Phase IV, Jigani Link Road, Bangalore 560099, India

6. Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492, United States

7. Discovery Toxicology, Bristol Myers Squibb Company, Route 206 & Province Line Rd, Princeton, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02132

Reference38 articles.

1. Neuropathic pain

2. The IASP classification of chronic pain for ICD-11: chronic neuropathic pain

3. Reappraising neuropathic pain in humans—how symptoms help disclose mechanisms

4. Herpes Zoster (Shingles) and Postherpetic Neuralgia

5. Management of Diabetic Peripheral Neuropathy

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