GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer-Reference-Cited by-同舟云学术

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

Published:2021-07-12 Issue:16 Volume:64 Page:11841-11856
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liang Jun¹^ORCID,Zbieg Jason R.¹^ORCID,Blake Robert A.¹,Chang Jae H.¹^ORCID,Daly Stephen²,DiPasquale Antonio G.¹,Friedman Lori S.¹,Gelzleichter Thomas¹,Gill Matthew²,Giltnane Jennifer M.¹,Goodacre Simon²,Guan Jane¹,Hartman Steven J.¹,Ingalla Ellen Rei¹,Kategaya Lorn¹,Kiefer James R.¹,Kleinheinz Tracy¹,Labadie Sharada S.¹,Lai Tommy³,Li Jun¹,Liao Jiangpeng³,Liu Zhiguo³,Mody Vidhi¹,McLean Neville²,Metcalfe Ciara¹^ORCID,Nannini Michelle A.¹,Oeh Jason¹,O’Rourke Martin G.²,Ortwine Daniel F.¹,Ran Yingqing¹,Ray Nicholas C.²,Roussel Fabien²,Sambrone Amy¹,Sampath Deepak¹,Schutt Leah K.¹,Vinogradova Maia¹,Wai John³,Wang Tao³,Wertz Ingrid E.¹,White Jonathan R.²,Yeap Siew Kuen²,Young Amy¹,Zhang Birong¹,Zheng Xiaoping³,Zhou Wei¹,Zhong Yu¹,Wang Xiaojing¹

Affiliation:

1. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

2. Charles River Discovery Research Services UK Limited, 7-9 Spire Green Center, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom

3. WuXi AppTec Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00847

Reference50 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries