Design and Evaluation of a Novel Peptide–Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease-Reference-Cited by-同舟云学术

Design and Evaluation of a Novel Peptide–Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease

Published:2022-01-04 Issue:1 Volume:65 Page:876-884
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Na¹²,Zhang Yichi¹,Lei Yingshou³,Wang Rui²^ORCID,Zhan Meimiao¹,Liu Jianbo²,An Yuhao²,Zhou Yaoqi³^ORCID,Zhan Jian³,Yin Feng¹²,Li Zigang¹²^ORCID

Affiliation:

1. State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China

2. Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen 518118, China

3. Institute for Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518032, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Shenzhen-Hong Kong Institute of Brain Science

Shenzhen Science and Technology Innovation Committee

Shenzhen Bay Laboratory

Beijing National Laboratory of Molecular Science

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02022

Reference36 articles.

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4. World Health Organization. Coronavirus Disease (COVID-2019) Situation Reports. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports (WHO, 2021).

5. Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19)

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