Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors-Reference-Cited by-同舟云学术

Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors

Published:2022-02-15 Issue:4 Volume:65 Page:3343-3358
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kajita Yuichi¹^ORCID,Ikeda Shuhei¹^ORCID,Yoshikawa Masato¹^ORCID,Fukuda Hiromi¹,Watanabe Etsurou¹,Yano Jason²,Lane Weston²,Miyamoto Maki¹,Ishii Tsuyoshi¹,Nishi Toshiya¹,Koike Tatsuki¹^ORCID

Affiliation:

1. Research, Takeda Pharmaceutical Company Ltd, 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan

2. Takeda California Inc., 9625 Towne Centre Drive, San Diego, California 92121, United States

Funder

Takeda Pharmaceutical Company

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01898

Reference31 articles.

1. Brain Cholesterol: Long Secret Life Behind a Barrier

2. Knockout of the Cholesterol 24-Hydroxylase Gene in Mice Reveals a Brain-specific Mechanism of Cholesterol Turnover

3. Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain

4. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

5. Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases

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