Structure–Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect-Reference-Cited by-同舟云学术

Structure–Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect

Published:2021-12-15 Issue:24 Volume:64 Page:17795-17812
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bavo Francesco¹,de-Jong Heleen¹,Petersen Jonas¹²,Falk-Petersen Christina Birkedahl¹,Löffler Rebekka¹,Sparrow Emma³,Rostrup Frederik¹,Eliasen Jannik Nicklas¹,Wilhelmsen Kristine S.¹,Barslund Kasper⁴,Bundgaard Christoffer⁴,Nielsen Birgitte¹,Kristiansen Uffe¹,Wellendorph Petrine¹^ORCID,Bogdanov Yury³,Frølund Bente¹^ORCID

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark

2. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark

3. Antibody and Vaccine Group, Centre for Cancer Immunology, MP127, University of Southampton Faculty of Medicine, Southampton, Hants SO16 6YD, United Kingdom

4. Translational DMPK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark

Funder

Cancer Research UK

Lundbeckfonden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00290

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1. GABA-A receptor subtypes in the brain: a paradigm for CNS drug discovery?