Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin-Reference-Cited by-同舟云学术

Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin

Published:2021-08-03 Issue:15 Volume:64 Page:11729-11745
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Oboh Edmund¹,Schubert Tanner J.¹,Teixeira Jose E.²,Stebbins Erin E.²,Miller Peter²,Philo Emily¹,Thakellapalli Haresh¹,Campbell Scott D.³,Griggs David W.³⁴,Huston Christopher D.²^ORCID,Meyers Marvin J.¹⁴^ORCID

Affiliation:

1. Department of Chemistry, Saint Louis University, Saint Louis, Missouri 63103, United States

2. Department of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont 05401, United States

3. Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, United States

4. Institute for Drug and Biotherapeutic Innovation, Saint Louis University, St. Louis, Missouri 63103, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01136

Reference47 articles.

1. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

2. Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study

3. Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

4. Outbreaks Associated with Treated Recreational Water — United States, 2000–2014

5. Association of early childhood diarrhea and cryptosporidiosis with impaired physical fitness and cognitive function four-seven years later in a poor urban community in northeast Brazil.

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Treating cryptosporidiosis: A review on drug discovery strategies;International Journal for Parasitology: Drugs and Drug Resistance;2024-08

2. Synthesis and characterization of self-assembly nanocomposite of ginger extract/cellulose of cotton supported by zinc oxide nanoparticle for destroying the Cryptosporidium parvum oocysts;Journal of Dispersion Science and Technology;2024-04-08

3. Identification of potent and orally efficacious phosphodiesterase inhibitors in sCryptosporidium parvum-infected immunocompromised mice;2023-09-26

4. Dual mechanism (sunlight/dark) of the self-assembly nitazoxanide drug on cellulose nanocrystal surface for destroying the Cryptosporidium parvum oocysts;International Journal of Biological Macromolecules;2023-08

5. Safe and effective treatments are needed for cryptosporidiosis, a truly neglected tropical disease;BMJ Global Health;2023-08