SAR of Novel 3-Arylisoquinolinones: <i>meta</i>-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules-Reference-Cited by-同舟云学术

SAR of Novel 3-Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules

Published:2022-03-15 Issue:6 Volume:65 Page:4783-4797
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Elhemely Mai A.¹²,Belgath Asma A.¹,El-Sayed Sherihan¹³,Burusco Kepa K.¹,Kadirvel Manikandan¹,Tirella Annalisa¹⁴^ORCID,Finegan Katherine¹,Bryce Richard A.¹^ORCID,Stratford Ian J.¹,Freeman Sally¹^ORCID

Affiliation:

1. Division of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester M13 9PT, U.K.

2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt

3. Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt

4. BIOtech Center for Biomedical Technologies, Department of Industrial Engineering, University of Trento, Via delle Regole 101, Trento 38123, Italy

Funder

Department for Business, Energy and Industrial Strategy, UK Government

Ministry of Higher Education and Scientific Research

Ministry of Higher Education

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01936

Reference57 articles.

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3. Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family

4. Disruption of Dihydronicotinamide Riboside:Quinone Oxidoreductase 2 (NQO2) Leads to Myeloid Hyperplasia of Bone Marrow and Decreased Sensitivity to Menadione Toxicity

5. Deficiency of NRH:Quinone Oxidoreductase 2 Increases Susceptibility to 7,12-Dimethylbenz(a)anthracene and Benzo(a)pyrene-Induced Skin Carcinogenesis

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