In Silico Modeling and Scoring of PROTAC-Mediated Ternary Complex Poses-Reference-Cited by-同舟云学术

In Silico Modeling and Scoring of PROTAC-Mediated Ternary Complex Poses

Published:2022-04-12 Issue:8 Volume:65 Page:6116-6132
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liao Junzhuo¹,Nie Xueqing¹,Unarta Ilona Christy²,Ericksen Spencer S.³^ORCID,Tang Weiping¹²³^ORCID

Affiliation:

1. School of Pharmacy, University of Wisconsin−Madison, Madison, Wisconsin 53705, United States

2. Department of Chemistry, University of Wisconsin−Madison, Madison, Wisconsin 53706, United States

3. Drug Development Core, UW Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin−Madison, Madison, Wisconsin 53705, United States

Funder

Wisconsin Alumni Research Foundation

Center for Scientific Review

University of Wisconsin-Madison

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02155

Reference71 articles.

1. Catalytic in vivo protein knockdown by small-molecule PROTACs

2. Phthalimide conjugation as a strategy for in vivo target protein degradation

3. Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

4. Waste disposal—An attractive strategy for cancer therapy

5. Induced protein degradation: an emerging drug discovery paradigm

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