Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies-Reference-Cited by-同舟云学术

Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies

Published:2022-03-30 Issue:7 Volume:65 Page:5317-5333
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Huang Ying¹^ORCID,Sendzik Martin²³,Zhang Jeff¹,Gao Zhenting¹,Sun Yongfeng¹,Wang Long¹,Gu Justin¹,Zhao Kehao¹,Yu Zhengtian¹,Zhang Lijun¹,Zhang Qiong¹,Blanz Joachim⁴,Chen Zijun¹,Dubost Valérie⁴,Fang Douglas¹,Feng Lijian¹,Fu Xingnian¹,Kiffe Michael⁴,Li Ling¹,Luo Fangjun¹,Luo Xiao¹,Mi Yuan¹,Mistry Prakash⁴,Pearson David⁴,Piaia Alessandro⁴,Scheufler Clemens⁴,Terranova Remi⁴,Weiss Andreas⁴,Zeng Jue¹,Zhang Hailong¹,Zhang Jiangwei¹,Zhao Mengxi¹,Dillon Michael P.²,Jeay Sebastien⁴,Qi Wei¹,Moggs Jonathan⁴,Pissot-Soldermann Carole⁴^ORCID,Li En¹,Atadja Peter¹,Lingel Andreas²⁴^ORCID,Oyang Counde¹

Affiliation:

1. Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China

2. Novartis Institutes for BioMedical Research, 5300 Chiron Way, Emeryville, California 94608, United States

3. Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

4. Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c02148

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