Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP-Deleted Cancers
Author:
Affiliation:
1. Mirati Therapeutics, San Diego, California 92121, United States
2. DSG, San Diego, California 92130, United States
3. ZoBio BV, J. H. Oortweg 19, 2333 CH Leiden, Netherlands
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01900
Reference49 articles.
1. Protein Arginine Methylation in Mammals: Who, What, and Why
2. Crystal structure of the human PRMT5:MEP50 complex
3. The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins
4. A Novel WD Repeat Protein Component of the Methylosome Binds Sm Proteins
5. Versatility of PRMT5-induced methylation in growth control and development
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