<i>N</i>-Substituted 5-(1<i>H</i>-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action-Reference-Cited by-同舟云学术

N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action

Published:2022-01-25 Issue:3 Volume:65 Page:1979-1995
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Golovanov Alexey¹,Zhuravlev Alexander¹,Cruz Alejandro²,Aksenov Vladislav¹,Shafiullina Rania¹,Kakularam Kumar R.³,Lluch José M.²⁴^ORCID,Kuhn Hartmut³,González-Lafont Àngels²⁴^ORCID,Ivanov Igor¹^ORCID

Affiliation:

1. Lomonosov Institute of Fine Chemical Technologies, MIREA─Russian Technological University, Vernadskogo Pr. 86, 119571 Moscow, Russia

2. Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain

3. Department of Biochemistry, Charite─University Medicine Berlin, Corporate Member of Free University Berlin, Humboldt University Berlin and Berlin Institute of Health, Charitéplatz 1, D-10117 Berlin, Germany

4. Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain

Funder

Ministerio de Ciencia, Innovaci?n y Universidades

Deutsche Forschungsgemeinschaft

Russian Foundation for Basic Research

Ministry of Science and Higher Education of the Russian Federation

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01563