Discovery of Dual MER/AXL Kinase Inhibitors as Bifunctional Small Molecules for Inhibiting Tumor Growth and Enhancing Tumor Immune Microenvironment-Reference-Cited by-同舟云学术

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Discovery of Dual MER/AXL Kinase Inhibitors as Bifunctional Small Molecules for Inhibiting Tumor Growth and Enhancing Tumor Immune Microenvironment

Published:2024-06-24 Issue:13 Volume:67 Page:10906-10927
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Li Mu-Chun¹²^ORCID,Lai You-Liang¹,Kuo Po-Hsien¹,Reddy Julakanti Satyanarayana¹,Chen Chih-Ming¹^ORCID,Manimala Julakanti¹,Wang Pei-Chen¹,Wu Ming-Shiem¹,Chang Chun-Yu¹,Yang Chen-Ming¹,Lin Chin-Yu¹,Huang Yu-Chen¹,Chiu Chun-Hsien¹,Chang Ling¹,Lin Wen-Hsing¹,Yeh Teng-Kuang¹,Yen Wan-Ching¹,Hsieh Hsing-Pang¹²³^ORCID

Affiliation:

1. Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350401, Taiwan, ROC

2. Biomedical Translation Research Center (BioTReC), Academia Sinica, Taipei City 115202, Taiwan, ROC

3. Department of Chemistry, National Tsing Hua University, Hsinchu City 300044, Taiwan, ROC

Funder

National Health Research Institutes

National Science and Technology Council

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00400

Reference41 articles.

1. Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment

2. Structure and functions of Mer, an innate immune checkpoint

3. Gas6/Axl Signaling Pathway in the Tumor Immune Microenvironment

4. Immunobiology of the TAM receptors

5. The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy

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