Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5)-Reference-Cited by-同舟云学术

Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5)

Published:2024-08-12 Issue:16 Volume:67 Page:14524-14542
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Buschbom-Helmke Silke¹,Wang Pengfei¹,Alcaide Anna¹,Miguez-Cabello Federico²,Carta Mario³,Viotti Julio S.³,Nielsen Birgitte¹,Mulle Christophe³,Bowie Derek²,Jørgensen Flemming Steen¹^ORCID,Pickering Darryl S.¹,Bunch Lennart¹^ORCID

Affiliation:

1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen OE, Denmark

2. Department of Pharmacology & Therapeutics, Faculty of Medicine, McGill University, H3G 0B1 Montréal, Canada

3. Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, University of Bordeaux, F-33000 Bordeaux, France

Funder

Agence Nationale de la Recherche

Centre National de la Recherche Scientifique

Lundbeck Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01311

Reference31 articles.

1. Pharmacology of ionotropic glutamate receptors: A structural perspective

2. Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

3. Resolution, absolute stereochemistry and molecular pharmacology of the enantiomers of ATPA

4. Pharmacological Characterization of the Competitive GLUK5 Receptor Antagonist Decahydroisoquinoline LY466195 in Vitro and in Vivo

5. Synthesis and Pharmacological Characterization of N3-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLUK5 Kainate Receptor Antagonists