Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist-Reference-Cited by-同舟云学术

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist

Published:2024-04-18 Issue:9 Volume:67 Page:7245-7259
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Balıkçı Esra¹²,Marques Anne-Sophie M. C.¹²,Bauer Ludwig G.¹²^ORCID,Seupel Raina¹²,Bennett James¹²^ORCID,Raux Brigitt¹²,Buchan Karly¹²,Simelis Klemensas¹²^ORCID,Singh Usha¹²,Rogers Catherine¹²,Ward Jennifer¹²,Cheng Carol¹²,Szommer Tamas¹²,Schützenhofer Kira³,Elkins Jonathan M.¹²^ORCID,Sloman David L.⁴^ORCID,Ahel Ivan³,Fedorov Oleg¹²,Brennan Paul E.¹²⁵,Huber Kilian V. M.¹²^ORCID

Affiliation:

1. Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, U.K.

2. Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, U.K.

3. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.

4. Departments of Discovery Chemistry, Merck & Co. Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

5. Alzheimer’s Research UK Oxford Drug Discovery Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7FZ, U.K.

Funder

Kungliga Tekniska Högskolan

Diamond Light Source

Wellcome Trust

Innovative Medicines Initiative

Ovarian Cancer Research Alliance

European Federation of Pharmaceutical Industries and Associations

Biotechnology and Biological Sciences Research Council

Cancer Research UK

Ontario Institute for Cancer Research

Royal Institution for the Advancement of Learning, McGill University

Publisher