Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML
Author:
Affiliation:
1. Janssen Research and Development, Spring House, Pennsylvania 19477, United States
2. Janssen Research and Development, Turnhoutseweg 30, B-2340 Beerse, Belgium
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00809
Reference42 articles.
1. Recent Advances in DHODH Inhibition for Acute Myeloid Leukemia
2. Leukemia Stem Cells in Acute Myeloid Leukemia
3. Genetic Abnormalities and Challenges in the Treatment of Acute Myeloid Leukemia
4. Cell differentiation in acute myeloid leukemia
5. Epigenetic Modifications in Acute Myeloid Leukemia: Prognosis, Treatment, and Heterogeneity
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1. Identification of isoquinolinone DHODH inhibitor isosteres;Bioorganic & Medicinal Chemistry Letters;2024-09
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