Study of the Conformational Dynamics of Prolyl Oligopeptidase by Mass Spectrometry: Lessons Learned-Reference-Cited by-同舟云学术

Study of the Conformational Dynamics of Prolyl Oligopeptidase by Mass Spectrometry: Lessons Learned

Published:2024-05-24 Issue:12 Volume:67 Page:10436-10446
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Van Elzen Roos¹^ORCID,Konijnenberg Albert²,Van der Veken Pieter³^ORCID,Edgeworth Matthew J.⁴,Scrivens James H.⁴,Fülöp Vilmos⁵⁶,Sobott Frank²⁷⁸^ORCID,Lambeir Anne-Marie¹^ORCID

Affiliation:

1. Laboratory of Medical Biochemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium

2. Laboratory of Biomolecular & Analytical Mass Spectrometry, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerp, Belgium

3. Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium

4. Waters/Warwick Centre for BioMedical Mass Spectrometry and Proteomics, School of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K.

5. School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.

6. Institute of Biochemistry and Medical Chemistry, Medical School, University of Pécs, 7624 Pécs, Hungary

7. Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K.

8. School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, U.K.

Funder

FP7 Health

Universiteit Antwerpen

Fonds Wetenschappelijk Onderzoek

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00866

Reference32 articles.

1. 5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions

2. The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

3. P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy

4. Native ion mobility-mass spectrometry and related methods in structural biology

5. Ion mobility-mass spectrometry of intact protein–ligand complexes for pharmaceutical drug discovery and development