Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor

Author:

Xiong Yan1,Greschik Holger2,Johansson Catrine3,Seifert Ludwig4,Gamble Vicki3,Park Kwang-su1ORCID,Fagan Vincent5,Li Fengling6,Chau Irene6,Vedadi Masoud78,Arrowsmith Cheryl H.69,Brennan Paul5,Fedorov Oleg5,Jung Manfred41011ORCID,Farnie Gillian5,Liu Jing1,Oppermann Udo31213,Schüle Roland21114,Jin Jian1ORCID

Affiliation:

1. Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States

2. Department of Urology and Center for Clinical Research, University Freiburg Medical Center, Freiburg 79106, Germany

3. Structural Genomics Consortium, Botnar Research Center, NIHR Oxford BRU, University of Oxford, Oxford OX3 7LD, U.K.

4. Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg 79104, Germany

5. Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K.; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K.

6. Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada

7. Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada

8. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

9. Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada

10. German Cancer Research Centre (DKFZ), Heidelberg 69120, Germany

11. German Cancer Consortium (DKTK), Freiburg 79104, Germany

12. Botnar Research Centre, University of Oxford, Oxford OX3 7LD, U.K.

13. Oxford Translational Myeloma Centre, University of Oxford, Oxford OX3 7LD, U.K.

14. CIBSS Centre of Biological Signalling Studies, University of Freiburg, Freiburg 79106, Germany

Funder

Deutsche Forschungsgemeinschaft

National Institutes of Health

Cancer Research UK

Fondation Leducq

Publisher

American Chemical Society (ACS)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3