Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent <i>In Vivo</i> Activities in Mouse Models of Hematological and Solid Tumors-Reference-Cited by-同舟云学术

Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent In Vivo Activities in Mouse Models of Hematological and Solid Tumors

Published:2024-08-05 Issue:16 Volume:67 Page:14370-14393
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tarr James C.¹,Salovich James M.¹,Aichinger Martin²,Jeon KyuOk¹,Veerasamy Nagarathanam¹,Sensintaffar John L.¹,Arnhof Heribert²,Samwer Matthias²,Christov Plamen P.³,Kim Kwangho³,Wunberg Tobias²,Schweifer Norbert²,Trapani Francesca²,Arnold Allison¹,Martin Florian²,Zhao Bin¹,Miriyala Nagaraju¹^ORCID,Sgubin Danielle¹,Fogarty Stuart¹,Moore William J.⁴,Stott Gordon M.⁴,Olejniczak Edward T.¹,Engelhardt Harald²^ORCID,Rudolph Dorothea²,Lee Taekyu¹,McConnell Darryl B.²^ORCID,Fesik Stephen W.¹^ORCID

Affiliation:

1. Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States

2. Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120 Vienna, Austria

3. Molecular Design and Synthesis Center, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37323-0146, United States

4. Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21701-4907, United States

Funder

Basic Energy Sciences

Center for Cancer Research

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01188

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