Examining Hemin and its Derivatives: Induction of Heme-Oxygenase-1 Activity and Oxidative Stress in Breast Cancer Cells through Collaborative Experimental Analysis and Molecular Dynamics Simulations

Author:

Alsharabasy Amir M.1ORCID,Lagarias Panagiotis I.2,Papavasileiou Konstantinos D.234ORCID,Afantitis Antreas234ORCID,Farràs Pau15ORCID,Glynn Sharon16,Pandit Abhay1ORCID

Affiliation:

1. CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway H91 W2TY, Ireland

2. Department of ChemoInformatics, Novamechanics Ltd., Nicosia 1070, Cyprus

3. Department of Chemoinformatics, Novamechanics MIKE, Piraeus 18545, Greece

4. Division of Data Driven Innovation, Entelos Institute, Larnaca 6059, Cyprus

5. School of Biological and Chemical Sciences, Ryan Institute, University of Galway, Galway H91 TK33, Ireland

6. Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway H91 YR71, Ireland

Funder

University of Galway

Science Foundation Ireland

Irish Research Council

European Regional Development Fund

Irish Centre for High-End Computing

Horizon 2020 Framework Programme

High-Performance Computing Facility of the Cyprus Institute

Publisher

American Chemical Society (ACS)

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