Identification of CDK4/6 Inhibitors as Small Molecule NLRP3 Inflammasome Activators that Facilitate IL-1β Secretion and T Cell Adjuvanticity-Reference-Cited by-同舟云学术

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Identification of CDK4/6 Inhibitors as Small Molecule NLRP3 Inflammasome Activators that Facilitate IL-1β Secretion and T Cell Adjuvanticity

Published:2024-08-20 Issue:17 Volume:67 Page:14974-14985
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Weiss Adam M.¹²^ORCID,Lopez Marcos A.¹²,Rosenberger Matthew G.¹,Kim Jeremiah Y.¹,Shen Jingjing¹,Chen Qing¹,Ung Trevor¹,Ibeh Udoka M.¹³,Knight Hannah Riley¹,Rutledge Nakisha S.¹,Studnitzer Bradley¹²,Rowan Stuart J.¹²^ORCID,Esser-Kahn Aaron P.¹^ORCID

Affiliation:

1. Pritzker School of Molecular Engineering University of Chicago 5640 South Ellis Avenue, Chicago, Illinois 60637, United States

2. Department of Chemistry University of Chicago 5735 South Ellis Avenue, Chicago, Illinois 60637, United States

3. Pritzker School of Medicine University of Chicago 924 East 57th Street, Chicago, Illinois 60637, United States

Funder

National Institute of Allergy and Infectious Diseases

Defense Threat Reduction Agency

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00516

Reference54 articles.

1. Emerging concepts in the science of vaccine adjuvants

2. Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

3. Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21

4. Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

5. Inflammasomes and adaptive immune responses

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